CRRT History

In 1977, Dr. Peter Kramer was the first to describe such type of therapy in the literature. It was named CAVH (Continuous Arterio-Venous Hemofiltration). The blood was moved from an artery to a vein through a hemofilter. Ultrafiltration rate was controlled by raising and lowering the drain bag.
Because of hypotension experienced by critically ill patients the blood flow of AV method, where the difference of pressure between artery and venous vessels is used to create the flow, is low and limits the volume of ultrafiltrate which can be obtained.

In 1982 FDA (Food and Drug Administration) approves CAVH.

From the early 80’s a blood pump and a double-lumen catheter in a large vein are used to provide a consistent blood, and thus ultrafiltration flow. This so called Veno-Venous technique has been since then been adopted and improved to become the most standard in CRRT.

In the 90’s the first fully automatic machines are made and become immediately popular in intensive care settings.

Since the beginning of the millenium, technology has been improved to achieve better clinical outcomes and reach high safety levels for the patients. With this philosophy in mind, Infomed has designed devices that for example :

In 2002, ADQI (Adequate Dialysis Quality Initiative) group gives the first consensus definition of ARF (Acute Renal Failure), the main reason to perform CRRT. Later the term AKI (Acute Kidney Injury) has appeared as a synonymous.

Today, CRRT is a routine therapeutic tool in intensive care settings with more than 100'000 ? treatments performed worldwide every year.

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